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This course serves as an advanced introduction to medical imaging with a focus on the physical, mathematical, and computational principles underlying modern imaging systems. Fundamental concepts of image formation, tomographic data acquisition, and image reconstruction are covered, along with the design and operation of major imaging modalities such as x-ray computed tomography, magnetic resonance imaging, and related technologies. The course also addresses contemporary artificial intelligence and deep learning methods for medical imaging, including learning-based image reconstruction, image analysis, and emerging clinical and research applications.

23 lecturesCurated by Course InstructorFree

How this course is taught

The AI avatar teaches, asks, evaluates, and remediates. An AI instructor in your professor's own voice delivers every lecture, pauses to ask you questions, grades your free-form answers with formative feedback, and a personal AI tutor picks up wherever you struggle. The human instructor monitors progress and curates the content.

Course syllabus

BMED 4590/6590, Medical Imaging

Credits and Contact Hours

4 credits, 4 contact hours

Instructor and Coordinator

Ge Wang

Textbook(s)

1. Fundamentals of Medical Imaging, Second Edition

Paul Suetens

Cambridge University Press, 2009

2. Machine Learning for Tomographic Imaging

Ge Wang, Yi Zhang, Xiaojing Ye, and Xuanqin Mou

IOP Publishing, 2019

Supplemental Materials

Additional journal articles, lecture notes, research papers, and educational resources will be provided throughout the course and made available through the course learning management system.

Catalog Description

This course provides an in-depth introduction to modern medical imaging, covering the physical, mathematical, computational, and engineering principles underlying major imaging modalities. Emphasis is placed on image formation, tomographic data acquisition, image reconstruction, and clinical applications. The course also introduces state-of-the-art artificial intelligence (AI) and deep learning (DL) methods for medical imaging, with particular attention to learning-based and data-driven tomographic reconstruction techniques. Students will gain both theoretical understanding and exposure to current research developments in medical imaging.

Prerequisites

BMED 2300 Bio-Instrumentation and Bio-Imaging, or equivalent background in biomedical imaging and instrumentation.

Course Classification

Elective undergraduate course and graduate course in Biomedical Engineering and related disciplines.

Course Outcomes

Students who successfully complete the course should be able to:

Understand the fundamental principles of medical imaging systems.
Explain the physical and mathematical foundations of image acquisition and reconstruction.
Describe the architecture and operation of major tomographic imaging modalities.
Understand the principles and applications of deep neural networks in medical imaging.
Perform basic machine learning tasks relevant to medical imaging applications.
Design, derive, or adapt computational methods and algorithms for medical imaging problems.
Analyze strengths, limitations, and clinical applications of different imaging modalities.
Develop a systematic understanding of current trends and state-of-the-art technologies in medical imaging and AI.

Student Outcomes

An ability to identify, formulate, and solve complex engineering problems by applying principles of engineering, science, and mathematics.
An ability to apply engineering design to produce solutions that meet specified needs with consideration of public health, safety, welfare, and societal factors.
An ability to communicate effectively with a range of audiences.
An ability to recognize ethical and professional responsibilities in engineering situations and make informed judgments.
An ability to function effectively on multidisciplinary teams.
An ability to develop and conduct appropriate experimentation, analyze and interpret data, and use engineering judgment to draw conclusions.
An ability to acquire and apply new knowledge using appropriate learning strategies.

BME Program Criteria

Apply principles of engineering, biology, physiology, physics, mathematics, and statistics to biomedical engineering problems.
Solve biomedical engineering problems involving interactions between living and non-living systems.
Analyze and evaluate biomedical engineering systems and imaging technologies.
Interpret data obtained from biological and biomedical systems.

Topics

Neural networks and deep learning; x-ray physics and imaging components; filtered backprojection; computed tomography (CT); cone-beam CT; spiral CT; interior CT; spectral CT; iterative reconstruction; learning-based image reconstruction; Maxwell equations; Bloch equations; magnetic resonance imaging (MRI); pulse sequences; image formation and reconstruction; advanced medical imaging modalities; artificial intelligence applications in medical imaging; and current research trends in medical imaging.

Software Requirements

Programming assignments and computational exercises may require the use of Python, TensorFlow, or equivalent machine learning and scientific computing software.

Grading Policy

Attendance and Participation: 10%
Homework Assignments: 30%
Midterm Examination: 30%
Final Examination: 30%

Optional project-based credit may be awarded at the instructor's discretion.

Academic Integrity

Students are expected to uphold the highest standards of academic honesty and professional conduct. All submitted work must represent the student's own effort unless collaboration is explicitly authorized. Any form of academic dishonesty, including plagiarism, cheating, fabrication, or unauthorized collaboration, may result in disciplinary action according to university policies.

Course Format

This course consists of lectures, demonstrations, programming exercises, homework assignments, examinations, and discussions of current research topics. Students are expected to actively engage with course materials and complete all required assignments to reinforce their understanding of medical imaging principles and applications.

Syllabus

Lectures
  • 1. Medical Imaging

  • 2. X-ray Physics

  • 3. FBP: Parallel- and Fan-Beam Geometry

  • 4. CT Reconstruction: Cone-Beam Approximation

  • 5. CT Reconstruction: Cone-Beam Exact

  • 6. CT Reconstruction: Spiral Cone-Beam

  • 7. Interior Tomography and Photon-Counting CT

  • 8. Nuclear Imaging

  • 9. Image Quality I

  • 10. Deep Learning

  • 11. Deep Imaging

  • 12. Deep Denoising

  • 13. MRI Physics

  • 14. Spin-Echo

  • 15. K-Space Theorem

  • 16. More MRI Topics

  • 17. Generative AI Models I

  • 18. Generative AI Models II

  • 19. Generative AI Models III

  • 20. Image Quality II

  • 21. Ultrasound Imaging

  • 22. Optical Imaging

  • 23. Foundation Model I

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